Combien d'outils expose ai.nullary/nullary ?

ai.nullary/nullary expose 35 outil(s). Le coût de contexte pour les charger tous est d'environ 13785 tokens (coût unique au chargement, pas par appel).

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ai.nullary/nullary

serveur MCP (Model Context Protocol) · Nullary 1.0.1

▸ Recherche & Web

[ Non encore testé ]

Verdict MCP Hub
Référencé dans l'annuaire. Seul le pentest comportemental fait foi, et il n'a pas encore été exécuté sur ce serveur.

streamable-httpType / transport

directAccès

~13785 tokensCoût de contexte

35Outils

Est-ce que ai.nullary/nullary est sûr ?

Au dernier audit MCP Hub, le serveur MCP « ai.nullary/nullary » est classé « Non encore testé ». Référencé dans l'annuaire. Seul le pentest comportemental fait foi, et il n'a pas encore été exécuté sur ce serveur. Le verdict est réévalué en continu ; consultez la fiche pour l'état à jour.

Méthode : MCP Hub analyse la description de chaque outil (couche 1) et, pour le verdict fort, exécute le serveur dans une micro-VM isolée avec leurres et réseau bloqué (couche 2). On publie des noms et des compteurs, jamais le contenu brut renvoyé par un outil.

Les 35 outils

get_compound≈ 436 tokens
A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- chembl_id · string · optionnel
  ChEMBL molecule ID, e.g. CHEMBL941.
- inchi_key · string · optionnel
  Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid).
- pubchem_cid · integer · optionnel
  PubChem Compound ID (CID).
Exemple d'appel
```
{"name": "get_compound", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "chembl_id": "texte", "inchi_key": "texte", "pubchem_cid": 1}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"compound": {}, "findings": [], "query_metadata": {}, "returned_count": 1}}
```

get_coverage≈ 205 tokens

Per-modality and per-source coverage stats (honest Phase-1 numbers).

Paramètres, retour & exemple (0)

Exemple d'appel

{"name": "get_coverage", "arguments": {}}

Exemple de retour

{"content": [{"type": "text", "text": "…"}], "structuredContent": {"total": 1, "by_modality": [], "curated_total": 1, "by_source_type": [], "query_metadata": {}}}

get_finding_provenance≈ 181 tokens
Full provenance + detail for a single finding by id.
Paramètres, retour & exemple (1)
Paramètres
- id · string · requis
  finding UUID
Exemple d'appel
```
{"name": "get_finding_provenance", "arguments": {"id": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"finding": {}, "query_metadata": {}}}
```
get_model_card≈ 203 tokens
Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
Paramètres, retour & exemple (1)
Paramètres
- target · string · requis
  gene symbol or UniProt accession (required)
Exemple d'appel
```
{"name": "get_model_card", "arguments": {"target": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"query_metadata": {}}}
```
get_target_landscape≈ 301 tokens
Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
Paramètres, retour & exemple (1)
Paramètres
- target · string · requis
  gene symbol or UniProt accession (required)
Exemple d'appel
```
{"name": "get_target_landscape", "arguments": {"target": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"summary": "texte", "by_outcome": [], "by_modality": [], "query_metadata": {}}}
```
list_models≈ 161 tokens
Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
Paramètres, retour & exemple (0)
Exemple d'appel
```
{"name": "list_models", "arguments": {}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"query_metadata": {}}}
```
list_top_targets≈ 236 tokens
Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
Paramètres, retour & exemple (2)
Paramètres
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- family · string · optionnel
  target family filter (optional)
Exemple d'appel
```
{"name": "list_top_targets", "arguments": {"limit": 1, "family": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"query_metadata": {}}}
```
search_adc_linker_failures≈ 462 tokens
ADC failures attributed to linker chemistry.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_adc_linker_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_admet_failures≈ 456 tokens
Small-molecule ADMET failures.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_admet_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_admet_failures_all_modalities≈ 466 tokens
ADMET failures across ALL modalities.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_admet_failures_all_modalities", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_ancestry_specific_failures≈ 463 tokens
Ancestry-specific CRISPR failures.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_ancestry_specific_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_bispecific_format_failures≈ 464 tokens
Bispecific format/engineering failures.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_bispecific_format_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_developability_failures≈ 462 tokens
Antibody developability failures.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_developability_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_drug_drug_interaction_failures≈ 444 tokens
Drug-drug interaction failures.
Paramètres, retour & exemple (5)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_drug_drug_interaction_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_adcs≈ 455 tokens
ADCs that failed at any stage.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_adcs", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_bispecifics≈ 460 tokens
Bispecifics that failed at any stage.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_bispecifics", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_clinical_antibodies≈ 466 tokens
Discontinued/terminated clinical antibodies.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_clinical_antibodies", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_essentiality_screens≈ 466 tokens
Non-dependency / failed essentiality screens.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_essentiality_screens", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_guides≈ 456 tokens
Failed/ineffective CRISPR guides.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_guides", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_oligonucleotides≈ 466 tokens
ASOs/siRNAs that failed engagement/developability.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_oligonucleotides", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_peptide_therapeutics≈ 462 tokens
Failed peptide therapeutics.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_peptide_therapeutics", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_protacs≈ 462 tokens
PROTACs that failed degradation/ternary/permeability.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_protacs", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_replications≈ 460 tokens
Findings that failed to replicate.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_replications", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_selectivity≈ 461 tokens
Small molecules that failed selectivity.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_failed_selectivity", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_failed_vaccines≈ 458 tokens
Failed/terminated vaccines (by pathogen/indication).
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- indication · string · optionnel
  disease/indication
Exemple d'appel
```
{"name": "search_failed_vaccines", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "indication": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_inactive_compounds≈ 462 tokens
Inactive small-molecule compound-target pairs.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_inactive_compounds", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_indication_history≈ 419 tokens
ALL failed approaches for an indication across every modality.
Paramètres, retour & exemple (4)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- indication · string · requis
  indication (required)
Exemple d'appel
```
{"name": "search_indication_history", "arguments": {"indication": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_mechanism_failures≈ 464 tokens
Approaches that failed for a mechanism (by target).
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_mechanism_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_oligo_delivery_failures≈ 462 tokens
Oligonucleotide delivery failures.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_oligo_delivery_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_pathogen_history≈ 417 tokens
Vaccine + antimicrobial + antibody failures for a pathogen.
Paramètres, retour & exemple (4)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- pathogen · string · requis
  pathogen name (required)
Exemple d'appel
```
{"name": "search_pathogen_history", "arguments": {"pathogen": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_peptide_stability_issues≈ 463 tokens
Peptide stability/half-life failures.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_peptide_stability_issues", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_protac_e3_issues≈ 462 tokens
PROTAC E3-ligase recruitment / ternary failures.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_protac_e3_issues", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_safety_failures≈ 463 tokens
Clinical/preclinical safety failures across modalities.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_safety_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_target_history≈ 420 tokens
ALL failed approaches against a target across every modality.
Paramètres, retour & exemple (4)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · requis
  UniProt accession or gene symbol (required)
Exemple d'appel
```
{"name": "search_target_history", "arguments": {"target": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```
search_vaccine_immunogenicity_failures≈ 466 tokens
Failed vaccine immunogen designs.
Paramètres, retour & exemple (6)
Paramètres
- tier · string · optionnel · curated | all
  Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
- limit · integer · optionnel
  Maximum number of findings to return (1–100, default 25).
- offset · integer · optionnel
  Number of findings to skip before this page, for pagination (default 0).
- target · string · optionnel
  UniProt accession or gene symbol
- outcome · string · optionnel
  outcome filter (inactive, failed_safety, terminated, …)
- compound · string · optionnel
  compound name, ChEMBL ID, or InChIKey
Exemple d'appel
```
{"name": "search_vaccine_immunogenicity_failures", "arguments": {"tier": "curated", "limit": 1, "offset": 1, "target": "texte", "outcome": "texte", "compound": "texte"}}
```
Exemple de retour
```
{"content": [{"type": "text", "text": "…"}], "structuredContent": {"findings": [], "has_more": true, "coverage_note": "texte", "query_metadata": {}, "returned_count": 1}}
```

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